环匹阿尼酸是一种由霉菌产生的真菌毒素，包括某些种类的青霉属和曲霉属。其毒性与其特异性和可逆性抑制肌内质网Ca2+-ATPase的能力有关(sarcoIC50 = 0.6微米)。[1]，[2]环匹阿尼酸不抑制多种其他类型的膜结合ATP酶。它有效抑制完整组织、平滑肌和内皮以及分离细胞中的SERCA。[3],[4]

产品性质：

Cas No.:18172-33-3

别名:环匹阿尼酸,NSC 117181

化学名: (6aS,11aR,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-6a,7,11a,11b-tetrahydro-2H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9(6H)-one

Canonical SMILES:OC1=C(C(C)=O)C(N2C(C)(C)[C@@H](CC3=C4C5=CNC4=CC=C3)[C@H]5[C@@H]21)=O

分子式:C20H20N2O3

分子量:336.39

溶解度:DMF: 30 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml

储存条件:Store at -20°C

注意事项：

1、为了您的安全和健康，请穿实验服并戴一次性手套操作。

2、请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

3、为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。

References:

[1]. Seidler, N.W., Jona, I., Vegh, M., et al. Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum. The Journal of Biological Chemisty 264(30), 17816-17823 (1989).

[2]. Uyama, Y., Imaizumi, Y., and Watanabe, M. Effects of cyclopiazonic acid, a novel Ca2+-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle. British Journal of Pharmacology 106, 208-214 (1992).

[3]. Mumtaz, S., Burdyga, G., Borisova, L., et al. The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries. Cell Calcium 49(1-4), 66-77 (2011).

[4]. Berra-Romani, R., Raqeeb, A., Torres-Jácome, J., et al. The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta. Journal of Vascular Research 49, 65-76 (2012).