CUDC-101是组蛋白去乙酰化酶的多靶点抑制剂。它被设计成直接抑制表皮生长因子受体(EGFR)和HER2以及I类和II类HDACs。已经表明，CUDC-101能够在体外和体内异种移植物模型中有效地抑制多种肿瘤类型的发展，包括拉帕替尼-和埃罗替尼-抗性癌细胞系。机制研究提供了证据，表明CUDC-101不仅直接抑制EGFR和HER2信号，而且间接减弱存活信号通路Akt、HER3和MET。

产品性质：

Cas No.:1012054-59-9

别名:7-[[4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基]氧基]-N-羟基庚酰胺,CUDC101, CUDC 101

化学名:7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide

Canonical SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO

分子式:C24H26N4O4

分子量:434.49

溶解度:≥ 21.7 mg/mL in DMSO

储存条件:Store at -20°C

注意事项：

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Reference:

[1].Cheng-Jung Lai, Rudi Bao, Xu Tao, Jing Wang, Ruzanna Atoyan, Hui Qu, Da-Gong Wang, Ling Yin, Maria Samson, Jeffrey Forrester, Brian Zifcak, Guang-Xin Xu, Steven DellaRocca, Hai-Xiao Zhai, Xiong Cai, William E. Munger, Mitchell Keegan, Carmen V. Pepicelli, and Changgeng Qian. CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity. Cancer Res May 1, 2010 70; 3647.