Batimastat(也称为BB-49)，[4-(N-羟基氨基)-2R-异丁基-3S-(硫代戊环-2-基硫代甲基)-琥珀酰-L-苯丙氨酸-N-甲基酰胺]是广谱基质金属蛋白酶(MMPs)的有效合成抑制剂，所述基质金属蛋白酶包括间质胶原酶(IC50 = 3 nM)、基质分解素(IC50 = 20 nM)、Mr 72，000 IV型胶原酶(IC50 = 4 nM)、Mr 92，000 IV型胶原酶(IC50 = 4 nM)它是一种低分子量(MW = 478)和肽样胶原底物类似物，由分别结合MMPs和催化活性锌原子的肽骨架和异羟肟酸基团组成。Batimastat在各种肿瘤模型中显示抗肿瘤和抗血管生成活性，包括卵巢癌移植物和人结肠肿瘤。

产品性质：

Cas No.:130370-60-4

别名:巴马司他; BB94

化学名: (2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-2-((thiophen-2-ylthio)methyl)succinamide

Canonical SMILES:CNC([C@@H](NC([C@@H]([C@H](CSC1=CC=CS1)C(NO)=O)CC(C)C)=O)CC2=CC=CC=C2)=O

分子式:C23H31N3O4S2

分子量:477.64

溶解度:≥ 23.88mg/mL in DMSO

储存条件:Store at 4°C

注意事项：

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References:

[1].Bernard Davies, Peter D. Brown, Nick East, Michael J. Crimmin, and Frances R. Balkwill. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Research 1993; 53: 2087-2091

[2].X. Wang, X. Fu, P.D. Brown, M. J. Crimmin, and R. M. Hoffman. Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Research 1994; 54: 4726-4728

[3].Raffaella Giavazzi, Angela Garofalo, Cristina Ferri, Valeria Lucchini, Elisabeth A. Bone, Stefania Chiari, Peter D. Brown, M. Ines Nicoletti, and Giulia Taraboletti. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xgenografts. Clinical Cancer Research 1998; 4: 985-992