西尼地平(FRC8653)是一种L型和N型双重钙通道阻滞剂，具有抗高血压、抗交感神经和神经保护活性。IC50值:目标:钙通道西尼地平在高血压患者中显示出肾脏和血管保护作用以及改善的压力反射敏感性。它还通过清除自由基和激活磷脂酰肌醇3-激酶途径，在大鼠局灶性脑缺血模型中表现出神经保护作用。

产品性质：

Cas No.:132203-70-4

别名:西尼地平; FRC-8653

化学名:3-O-(2-methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCOC

分子式:C27H28N2O7

分子量:492.52

溶解度:≥ 24.6mg/mL in DMSO

储存条件:4°C, protect from light

注意事项：

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References:

[1]. Masuda T, Ogura MN, Moriya T, et al. Beneficial effects of L- and N-type calcium channel blocker on glucose and lipid metabolism and renal function in patients with hypertension and type II diabetes mellitus. Cardiovasc Ther. 2011 Feb;29(1):46-53. doi: 10

[2]. Morimoto S, Yano Y, Maki K, Iwasaka T. Renal and vascular protective effects of cilnidipine in patients with essential hypertension. J Hypertens. 2007 Oct;25(10):2178-83.

[3]. Takahara A, Konda T, Enomoto A, Kondo N. Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model. Biol Pharm Bull. 2004 Sep;27(9):1388-91.

[4]. Murai Y, Uneyama H, Ishibashi H et al. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 2000 Jan 31;854(1-2):6-10.