乳孢素是一种从链霉菌中分离出的微生物代谢产物，现已广泛用作20S蛋白酶体的选择性抑制剂[1],[2],[3]。乳孢素首先通过其在几种肿瘤细胞系中诱导分化和抑制细胞周期进展的能力而被表征。在2到10微米的浓度下，乳孢素能够诱导神经母细胞瘤细胞系Neuro2a的神经突起的生长[4]。乳孢素不可逆地烷基化20S蛋白酶体的X亚基。蛋白酶体肽酶活性的共同抑制导致各种泛素化蛋白的积累，这些蛋白本应快速降解。因此，乳孢素的效应是多样的，且在所处理的细胞中的信号蛋白的表达模式中具有重要的依赖性。

产品性质：

Cas No.:133343-34-7

别名:蛋白酶体抑制剂,乳孢素

化学名: 2-acetamido-3-[3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid

Canonical SMILES:CC1C(C(NC1=O)(C(C(C)C)O)C(=O)SCC(C(=O)O)NC(=O)C)O

分子式:C15H24N2O7S

分子量:376.42

溶解度:1mg/mL in ethanol, 20mg/mL in DMSO, or in DMF

储存条件:Store at -20°C

注意事项：

为了您的安全和健康，请穿实验服并戴一次性手套操作。

References:

[1]. Omura, S., Fujimoto, T.T., Otoguro, K., et al. Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. Journal of Antibiotics 44, 113-116 (1991).

[2]. Corey, E.J., and Reichard, G.A. Total synthesis of lactacystin. Journal of the American Chemical Society 114, 10677-10678 (1992).

[3]. Fenteany, G., and Schreiber, S.L. Lactacystin, proteasome function, and cell fate. The Journal of Biological Chemisty 273(15), 8545-8548 (1998).

[4]. Fenteany, G., Standaert, R.F., Reichard, G.A., et al. A β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proceedings of the National Academy of Sciences of the United States of America 91, 3358-3362 (1994).