AUY922 (NVP-AUY922)是热休克蛋白90 (HSP90)的有效的新型合成间苯二酚基异恶唑酰胺抑制剂。[1]是一种小分子，分子式为C26H31N3O5，分子量为465.5。它对Hsp90有更高的亲和力，并可在HSP 90N-末端结构域的ATP结合位点找到。[2]热休克蛋白90 (HSP90)是细胞生长和存活的关键调节物的稳定性所必需的分子伴侣。NVP-AUY922以大约2至40 nmol/L的GI50值有效地抑制胃癌细胞系的增殖，并显著诱导生长因子受体和其他客户蛋白的降解。[3]

产品性质：

Cas No.:747412-49-3

别名:VER-52296, AUY-922, AUY 922, Luminespib

化学名: (5Z)-N-ethyl-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-[4-(morpholin-4-ylmethyl)phenyl]-2H-1,2-oxazole-3-carboxamide

Canonical SMILES:CCNC(=O)C1=C(C(=C2C=C(C(=CC2=O)O)C(C)C)ON1)C3=CC=C(C=C3)CN4CCOCC4

分子式:C26H31N3O5

分子量:465.5

溶解度:≥ 23.3 mg/mL in DMSO, ≥ 100.6 mg/mL in EtOH with ultrasonic

储存条件:Store at -20°C

注意事项：

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References:

[1] Suzanne A. E, Andy M, Florence I. R, et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis. Cancer Res. 2008, 68. 2850-2860.

[2] Tsuyoshi U, Kazunori T, Shinichi T, Midori A, Munenori T, et al. Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer. Lung Cancer. 2012, 76. 26-31.

[3] Kyung-Hun L, Ju-Hee L, Sae-Won H, Seock-Ah I, et al. Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins. Cancer Sci. 2011, 102. 1388–1395.