Cyclopamine 是Hedgehog通路的拮抗剂，细胞实验中IC50=46 nM。它还是选择性Smo抑制剂。

环巴胺的EC50是10.57微米，这是通过FXR-bla(法尼基X受体-β-内酰胺酶)分析确定的[3]。 Hh信号通路在胚胎发育和肿瘤发生中起着关键作用[4]。Hh信号通路在广泛的人类组织中显示出调节细胞增殖和分化的显著性。它与许多人类恶性肿瘤中的异常细胞存活有关，从基底细胞癌和髓母细胞瘤到小细胞肺、胃肠道、乳腺和前列腺肿瘤[1]。

暴露于环巴胺的胚胎导致可见的外部缺陷，包括独眼畸形、长鼻形成、小眼症、胸部前凸、阿米莉亚和体型减小。对胃肠器官的检查显示了严重的缺陷，包括肠管长度缩短和前肠衍生器官中的间充质细胞数量减少。在十二指肠、胃和背胰腺中也发现了异位结构[5]。

产品性质：

Cas No.：4449-51-8

别名：环巴胺; 11-Deoxojervine

化学名： (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol

Canonical SMILES CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1

分子式：C27H41NO2

分子量：411.62

溶解度：≥ 6.9mg/mL in DMSO

储存条件：Store at -20°C

注意事项：

为了您的安全和健康，请穿实验服并戴一次性手套操作。

References:

[1].  Marc J. Meth and Jeffrey M. Weinberg. Cyclopamine: Inhibiting Hedgehog in the Treatment of Psoriasis. Continuing Medical Education, 2006, 78: 185-188.

[2].  Jun Che, Fu-Zheng Zhang, Chao-Qian Zhao, et al. Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti?proliferative, anti?invasive and anti?estrogenic potency in human breast cancer cells. Oncology Letters, 2013, 5: 1417-1421.

[3].  Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, et al. Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor. Scientific Reports, 2014, 4: 6437.

[4].  Robert J. Lipinski, Paul R. Hutson, Paul W. Hannam, et al. Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse. Toxicological Sciences, 2008, 104(1):189-197.

[5].  Seung K. Kim and Douglas A. Melton. Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor. Proc. Natl. Acad. Sci. USA, 1998, 95: 13036-13041.