Panobinostat，即LBH589，是一种新的和有效的基于异羟肟酸的脱乙酰酶抑制剂(DACis ),在低纳摩尔浓度下抑制广谱组蛋白脱乙酰酶(HDAC ),包括所有1、2和4类HDAC酶。根据以前的研究，它不仅通过胱天蛋白酶激活和聚(ADP-核糖)聚合酶(PARP)切割诱导多发性骨髓瘤(MM)细胞的凋亡，而且还以时间和剂量依赖的方式在费城染色体阴性(Ph-)急性淋巴细胞白血病(ALL)细胞系(T细胞MOLT-4和前B细胞Reh)中诱导有效的细胞生长抑制、细胞周期停滞和凋亡，这与组蛋白(H3K9和H4K8)超乙酰化的诱导、p21和p27的激活相关

产品性质：

Cas No:404950-80-7

别名:帕比司他; LBH589; NVP-LBH589

化学名:(E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide

Canonical SMILES:CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO

分子式:C21H23N3O2

分子量:349.43

溶解度:≥ 17.47mg/mL in DMSO

储存条件：Store at -20°C

注意事项：

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References:

[1].Wenlin Shao, Joseph D. Growney, Yun Feng, Gregory O’Connor, Minying Pu, Wenjing Zhu, Yung-Mae Yao, Paul Kwon, Stephen Fawell and Peter Atadja. Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: defining molecular mechanisms of resistance. Int. J. Cancer: 127, 2199-2208 (2010)

[2].Laurence Catley, Ellen Weisberg, Tanyel Kiziltepe, Yu-Tzu Tai, Teru Hideshima, Paola Neri, Pierfrancesco Tassone, Peter Atadja, Dharminder Chauhan, Nikhil C. Munshi and Keneth C. Anderson. Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood (2006); 108(10): 3441-3449

[3].Anna Scuto, Mark Kirschbaum, Claudia Kowolik, Leo Kretzner, Agnes Juhasz, Peter Atadja, Vinod Pullarkat, Ravi Bhatia, Stephen Forman, Yun Yen, and Richard Jove. The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood (2008); 111(10):5093-5100