细胞松弛素B是一种可渗透细胞的真菌毒素，它与肌动蛋白的倒刺端结合，可逆地抑制肌动蛋白丝的伸长和缩短。[1]通过破坏肌动蛋白聚合，细胞松弛素B阻断不同的细胞功能，包括细胞分裂、迁移、吞噬作用、胞吐作用、趋化性和葡萄糖转运。[2，3，4]细胞松弛素B广泛用于细胞学研究，包括依赖于肌动蛋白聚合的许多过程中的任何一个。[5，6，7]

产品性质：

Cas No.：14930-96-2

别名：细胞松弛素B; Phomin

Canonical SMILES： O=C1N[C@@H](CC2=CC=CC=C2)[C@@]3([H])[C@]14[C@](/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(O4)=O)([H])[C@H](O)C([C@H]3C)=C

分子式：C29H37NO5

分子量：479.61

溶解度：DMSO: ≥ 100 mg/mL (208.50 mM); Ethanol: 25 mg/mL (52.13 mM)

储存条件：Store at -20°C

注意事项：

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References:

[1]Theodoropoulos, P.A., Gravanis, A., Tsapara, A., et al.Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end cappingBiochem. Pharmacol.47(10)1875-1881(1994) [2].Steinberg, M.S., and Wiseman, L.L.Do morphogenetic tissue rearrangements require active cell movements? The reversible inhibition of cell sorting and tissue spreading by cytochalasin BJ. Cell Biol.55606-615(1972)

[3].Spudich, J.A., and Lin, S.Cytochalasin B, its interaction with actin and actomyosin from muscle (cell movement/microfilaments/rabbit striated muscle)Proc. Natl. Acad. Sci. USA69(2)442-446(1972) [4].Estensen, R.D., and Plagemann, P.G.W.Cytochalasin B: Inhibition of glucose and glucosamine transportProc. Natl. Acad. Sci. USA69(6)1430-1434(1972)

[5].Snezhko, A., Barlan, K., Aranson, I.S., et al.Statistics of active transport in Xenopus melanophores cellsBiophys. J.993216-3223(2010)

[6].Yu, Y., Dumollard, R., Rossbach, A., et al.Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturationJ. Cell. Physiol.224(3)672-680(2010)

[7].Yu, Y., Maguire, T.G., and Alwine, J.C.Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infectionJ. Virol.85(4)1573-1580(2011)