阿霉素是一种来源于细菌培养物的半合成抗癌剂。[1]它是一种蒽环类抗生素。它被广泛用于血癌、实体瘤和肉瘤。 盐酸阿霉素嵌入DNA双链并抑制DNA拓扑异构酶II的进程，停止复制过程。[2]盐酸阿霉素还诱导组蛋白从开放染色质中逐出，导致DNA损伤和表观遗传失调。[3]

    盐酸阿霉素通过静脉给药。大约75%的多柔比星及其代谢物与血浆蛋白结合。盐酸阿霉素不穿过血脑屏障。主要通过胆汁排泄，50%的药物从体内不变地消除。剩余的经历单电子还原、双电子还原和去糖苷化。主要代谢物是一种有效的膜离子泵抑制剂，与心肌病有关。[4]

产品性质：

Cas No.:25316-40-9

别名:盐酸阿霉素; Hydroxydaunorubicin hydrochloride

化学名: (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride

Canonical SMILES CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl

分子式:C27H29NO11.HCl

分子量:579.98

溶解度:33.3mg/ml in Water(Need ultrasonic);DMSO : >20 mg/mL (34.48 mM; Need ultrasonic)

储存条件:4°C, protect from light

注意事项：

为了您的安全和健康，请穿实验服并戴一次性手套操作。

References:

[1]Brayfield, A, ed. (2013). Doxorubicin. Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 15 April 2014.

[2]Pommier Y., et al. (2010). DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chemistry & Biology 17 (5): 421–433.

[3]Pang, B., et al. (2013). Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nature Communications 4 (5): 1908

[4]Boucek RJ., et al. (1987). The major metabolite of doxorubicin is a potent inhibitor of membrane-associated ion pumps. A correlative study of cardiac muscle with isolated membrane fractions. J of Biol Chem 262: 15851-15856.