Hh-Ag1.5 (SAg1.5) 是一种有效的 Hedgehog (Hh) 激动剂，EC50 为 1 nM。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态，从而挽救了肝衰竭。

    HhAg1.5 (5微米；3周)促进从体外非损伤肝脏富集的静止CD133+ CD45-肝干细胞(Hh3A细胞)的显著扩增[2]。Hh-Ag1.5完全与含Smo的膜结合，Ki值为0.52 nM[3]。Smo激动剂SAG-1.5显示出纳摩尔量级的Gli反应性报道活性的效力刺激，EC50为7 nM[4]。

产品性质：

Cas No.:612542-14-0

别名 SAg1.5

分子式:C28H26ClF2N3OS

分子量:526.04

溶解度:DMSO : 50 mg/mL (95.05 mM; Need ultrasonic)

储存条件:Store at -20°C

注意事项：

为了您的安全和健康，请穿实验服并戴一次性手套操作。

References:

[1]. Randall W King. Roughing Up Smoothened: Chemical Modulators of Hedgehog Signaling. J Biol. 2002 Nov 6;1(2):8.

[2]. Abhisek Mitra, et al. A Small Molecule Hedgehog Agonist HhAg1.5 Mediated Reprogramming Breaks the Quiescence of Noninjured Liver Stem Cells for Rescuing Liver Failure. Transl Res. 2019 Mar;205:44-50.

[3]. Maria Frank-Kamenetsky, et al. Small-molecule Modulators of Hedgehog Signaling: Identification and Characterization of Smoothened Agonists and Antagonists. J Biol. 2002 Nov 6;1(2):10.

[4]. Cynthia M Rominger, et al. Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor. J Pharmacol Exp Ther. 2009 Jun;329(3):995-1005.